Mole-Rats Could Hold the Key to Living LongerPlus, when did claret get so good and why did Shackleton's ship Endurance sink? Historical updates aplenty.
Welcome back to the Abstract! These are the studies this week that lived long, played hard, crashed out, and topped it off with a glass of claret.
First off, it’s Naked Mole-Rat Week! Or at least it should be, given that there are multiple new studies about these rodents, which are neither moles nor rats, but are certifiably naked. Then: dogs on benders; ships on ice; and an aged wine with notes of oak, blackberry, and aggressive trade policy.
The age of Man is over; the time of the Mole-Rat has come
What a whirlwind week it’s been for the naked mole-rat beat, with studies that shed light into the complex social behavior of these burrowing rodents as well as their extreme longevity. Let’s make like a naked mole-rat and dig in!
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Naked mole-rats didn’t get the memo about being a normal mammal and instead opted for a “eusocial” society similar to insects that is ruled by a colony queen with an entourage of breeder males, which are supported by a caste system of non-breeding workers. It’s super weird, but it seems to be working out for them because they can live to nearly 40 years old—ten times longer than most animals their size—and they are highly resistant to cancer and a host of other deathbringers.
Scientists took a closer look at the palace intrigue of these rodents by setting up several colonies in laboratory conditions and tracking their movements with microchips. The results revealed that queens are bossy bullies that get so tired from shoving their subjects around that they have to take frequent royal naps.
Non-breeding workers, meanwhile, fell into six main “clusters” including cleaners, transport specialists, caretakers, diggers, and a group that just kind of idly loafs around (my spirit mole-rat cluster).
“Breeding females patrol burrows and display agonistic dominance toward nonbreeders paralleling queen aggression in primitively eusocial insects,” said Masanori Yamakawa of Kumamoto University. Meanwhile, non-breeding “cluster 1 individuals (high mobility and garbage occupancy) may serve as transport specialists, whereas those in cluster 4 (low mobility and frequent occupancy of nonfunctional chambers) may engage primarily in digging tasks. Cluster 5 individuals, who frequently occupied toilet chambers, may contribute to cleaning-related roles.”
In addition to this window into mole-rat social behavior, a new genetic analysis identified the critical role of an enzyme called cGAS, a common component in animal immune systems, in extending the lives of these subterranean super-agers.
Whereas cGAS may hinder DNA repair in most animals, including humans and mice, the naked mole-rat has evolved a version of the enzyme with four modified amino acids that enhances DNA repair . Naturally, the researchers also engineered some fruit flies with this naked mole rat enzyme—you gotta mess with fruit flies or it’s not science—and lo and behold, the juiced flies lived to about 70 days, roughly ten days longer than the control group.
“Our work provides a molecular basis for how DNA repair is activated to contribute to the exceptional longevity during evolution in naked mole-rats,” said researchers led by Yu Chen of Tongji University in Shanghai. “These findings support the notion that efficient DNA repair decelerates the aging process and raise the possibility that targeting cGAS to enhance DNA repair could provide an intervention strategy for promoting longevity.”
All those past adventurers were looking for the Fountain of Youth in the wrong places; it wasn’t in some beautiful tropical grove, but rather a stanky underground rodent pit.
Dogs can literally get addicted to the game, according to a study that probed “‘excessive toy motivation” in domestic dogs as “a potential parallel to behavioral addictions in humans.” What this means in practice is that researchers enlisted 105 dogs to play with a lot of really fun toys and about a third of them got totally hooked.
Thirty-three of the playful pooches “exhibited behaviors consistent with addictive-like tendencies including an excessive fixation on toys, reduced responsiveness to alternative stimuli, and persistent efforts to access toys,” said researchers led by Alja Mazzini of the University of Bern. “Dogs [are] the only non-human species so far that appears to develop addictive-like behaviours spontaneously without artificial induction.”
A bull terrier during tug-of-war play. Image: Alja Mazzini
While this an interesting scientific conclusion, the study is perhaps most notable for producing delightful footage of dogs in the midst of full-on toy benders. Like all of us who struggle with bad habits and fixations, these dogs will just have to take it one play at a time.
Endurance, the ship crushed by ice in 1915 during Ernest Shackleton's Antarctic expedition, was actually not all that endurant, according to Jukka Tukuri of Aalto University who concludes in a new study that “Shackleton was well aware of the risks related to the strength of Endurance, but chose to use it anyway.”
“This ship is not as strong as the Nimrod constructionally” wrote Shackleton of Endurance in a letter to his wife in 1914, comparing it to his previous Antarctic ride. “There is nothing to be scared of as I think she will go through ice all right only I would exchange her for the old Nimrod any day now except for comfort.”
You have to love the phrase “there is nothing to be scared of” in a letter from a guy on his way to the South Pole in a rickety ship that is definitely going to sink the following year. I’m sure Mrs. Shackleton was totally comforted by this! Tukuri provides many other fascinating diary entries to support his conclusion that “Endurance was not among the strongest ships of its time.”
That said, Endurance spent more than a century two miles under the Antarctic seas before the wreck was amazingly rediscovered and photographed in 2022. It’s still looking pretty good, even if Shackleton’s decision to set sail in it does not hold up as well.
To fight off that polar chill, let’s warm up for the (North American) long weekend with a really, really aged glass of wine. A new study upends the traditional narrative about the emergence of Bordeaux claret as a desired wine in the 1600s, suggesting it was not strictly developed in response to tariffs (Sike! I used wine to lure you into a disguised tariff story).
“The advent of a stronger, darker style of Bordeaux red wine, known as claret, in the English market has drawn substantial scholarly interest because it played a pivotal role in the balance of trade and international political economy during the eighteenth century,” said author Charlie Leary, a wine historian.
“Economic historians have posited that Bordeaux vignerons developed high-quality, high-priced claret in response to England’s fixed, volume-based tariffs on French wine,” he continued. “This article…shows that the new claret style pre-existed England’s tariff regime.”
With that, cheers to lost years and jeers to economic fears.
