Hello! For the next month-and-a-bit, Everything Is Amazing is on a break - so as a free reader, I’m afraid you’re not getting anything brand new from me until mid-November. That means you’re missing everything I’m be writing for paid subscribers - and you also won’t be able to follow along on my science-driven quest to get a good night’s sleep, which is the subject of this free edition, a re-run of a newsletter I first ran in 2024. If you want to follow along and read everything else in EiA’s paywalled archives - or you just feel you want to support an independent science newsletter like this one (thank you!) - you can join EiA’s 820+ supporters below: 48 Hours to Total Meltdown: This is Your Body on No Sleep“Are you ok? Did you hear what I just said?”
Hello again! This is Everything Is Amazing, a newsletter about science, applied curiosity, and why all our maps could be the wrong way round. As I announced recently, I’ll soon be starting a new series on getting a better night’s sleep that will be behind the paywall - so as a run-up to that, here’s a story I originally published last year. It lays out exactly why sleep is so thunderously important to our health, and how quickly and how completely we fall apart without it. Forward we go to sleeplessness and horror - accompanied by a gruff, British voiceover from the idiot who writes this newsletter.
When I first started writing for a living, my head was filled with a lot of damn-fool notions about writing - the kind you’d never hear from a highly accomplished veteran, but you would hear from someone on social media whose only body of work was a loud, desperate-sounding need to appear authoritative. Since I was learning to be Extremely Online a lot quicker than I was learning to write, I internalised a lot of those confidently wrong ways to become A Proper Writer. One of these was around intentional sleep deprivation, to stimulate the imagination. It’s true that as you push far beyond your normal sleep cycle, you reach a point where you’re hallucinating on your feet. Woah! Wouldn’t that be a good source of really imaginative and out-the-box thinking? suggested the person whose tweet I can’t now find, probably because they’re now either deceased or working in investment banking. Because of the amount of ridicule they got, including from medical doctors, I quickly learned this was a terrible idea. But I remained curious about this - and on my old blog, I wrote the following piece, which I’ve updated after chatting to my better half, Dr. Mariana Calleja Ross, who is a doctor. Mariana is also writing a newsletter, and recently ran a mini-course on handling stress in which sleep plays a big part. She knows her stuff. Sign up to her for free below:  So, scientifically speaking - what actually happens to your body when you refuse to sleep? In short: it’s a living nightmare.
A third of your life (around 230,000 hours) will be spent unconscious. It sounds ridiculous, even wasteful – yet if you don’t ensure you’re spending around 7 to 9 hours a day in the mysterious state of radically altered consciousness we call “sleep”, you’ll quickly fall apart in ways that are nerve-wracking to contemplate. How quickly? Let’s take a look. Hour 18For whatever important or foolish reason, you’re still up – and it’s starting to get uncomfortable. Getting sleepy is a remarkable thing. Your head nods, your eyelids feel heavy, and your thoughts congeal – and it’s all entirely involuntary, operating to a biological schedule you have no direct control over and very little hope of fighting for very long. It’s as demanding as the urge to pee, and for good reason: the staggeringly complex factory of our body requires regular downtime for maintenance, and our brain knows how important this is. But you’re a modern human, and you think you know better. Fuelled by caffeine, bright artificial light and an alarming amount of stimulation, you’re burning the midnight oil like never before. You power past the 940-minute mark (the average amount of time UK folk stay awake) and keep going. Things are about to get really grim. Fortunately, you won’t remember much of it - which is why sleep-depriving yourself to come up with great ideas is a mug’s game. It’s bleakly ironic that one of the first casualties of sleep deprivation is your ability to form memories. It’s like your brain is an email Inbox that hits capacity: anything new will just bounce right out again. Your problem-solving skills are similarly impaired, along with your ability to make quick decisions. You can’t think, you can’t decide, you can’t organise anything inside your head – so you default to the last thing you were doing, because it’s easier to just keep going. This kind of “brain fog” will have catastrophic consequences a few hours from now. Hour 20You spill your third coffee of the night on your lap – and it takes you a few seconds to even notice. Your hand-eye coordination is tanking, making you clumsy, slow to react and increasingly dangerous to be around. The night seems young – but you’re already in a state equivalent to being legally drunk. At this part of the day, when you’re normally asleep, your pineal gland (a pea-sized lump near the centre of your brain) starts squirting out melatonin, a hormone that regulates your sleep cycle. Melatonin is like a klaxon announcing the end of your body’s daily work shift – a signal that it’s time to down tools and get everything fixed and recharged for the next day’s grind. But by staying awake, pouring white light into your eyes and caffeine into your gullet, you’re suppressing melatonin production and attempting to override the wisdom of your body clock’s schedule. Like other animals, human beings run on circadian rhythms – daily cycles of activity that combine to make a largely self-sustaining, largely self-repairing system. When you’re awake, your body is doing one set of activities. When you sleep, it switches to another. The combined effect of those wake-time and sleep-time processes together is your continued existence as a living, breathing person. It’s how you’ve stayed alive until today. But now you’re in real trouble. Your blood pressure is spiking dangerously. On a normal day, it rises more or less steadily from the moment you wake, and drops again as you sleep – making the latter a natural form of blood pressure medication. Even a single day’s interrupted sleep can make this deadly. Every year when Spring Daylight Saving Time kicks in and the clocks go forward, robbing everyone of an hour of sleep, there’s a 20-25% increase in heart attacks – and a roughly equivalent drop at the end of the year when the clocks fall back. Right now, there’s nothing stopping your hypertension. You’re like a nuclear reactor without cooling rods. If you’re young and fit, the risk of stroke or heart failure will be a little lower compared to some – but videogamer Chen Rong-yu was just 23 years old when his heart gave out, in front of a screen in an internet cafe in Taiwan, after spending 23 hours in a row playing League Of Legends. You’re also not feeling that great. Your sleep cycle produces the hormone testosterone, vital for building strength, muscle mass and bone density in both men and women (in whom it combines with estrogen to provide the same effect). You’re feeling weaker and listless, and everything’s more of an effort – so your stress levels climb, releasing cortisol which helps you keep awake at the cost of letting the insulin in your body do its job. Congrats, night-owl: you’re now on the road to type 2 diabetes. There’s also that tickly cough you’re getting: as pro-inflammatory proteins build up in your body (normally flushed out during sleep) and your immune cells decline in number (normally topped up during sleep), you’re way more likely of developing something nasty in the long run – like cancer, which is why night-time shift-work is now classed as carcinogenic. You’re feeling really bad. But don’t worry – that awareness won’t last long. Hour 24You’re a day without sleep now, and you realise someone’s talking to you. Of course you didn’t. Your body is panicking because you’ve ignored every danger sign it’s thrown at you so far, and now it’s using its last desperate trick: pulling the plug completely. For 10-30 second bursts, your brain is shutting itself down, even while the rest of you appears awake. Your eyes are open, you’re moving, you may even be talking to people – but you’re definitely not present. It’s called microsleeping – a deceptively benign term for something that kills at least 1500 people every year in the U.S. alone. Occasionally, the consequences can literally be devastating. At 1.23am on the 24th April 1986, the sleep-deprived, repeatedly-microsleeping shift workers at the Chornobyl nuclear power plants made an error that started the worst nuclear power accident in human history. A full day’s unbroken wakefulness is called Total Sleep Deprivation, but again, don’t let that term fool you. Things are about to get a hell of a lot worse. Hour 36Somehow, for reasons that surely aren’t worth what you’re currently putting yourself through, you’re still awake. It’s been a full day and a half of keeping your eyes open, and you’re about to lose your best chance of saving yourself. In a 2007 study, Matthew Walker and a team at Berkeley and Harvard studied 24 healthy individuals who hadn’t slept for 35 hours. In each person, they found their amygdala – believed to be a major processing centre for emotions in the brain – had become far more reactive to negative stimuli, along with a “loss of top-down, prefrontal control”. The apparent upshot of all this: you become more depressive and judgmental, you take things a lot harder, and you lose your ability to put how you’re feeling into the wider context of what you know to be true. Any decisions you make at this point are increasingly, maybe severely irrational. That’s why you decide to stay up a while longer. Hour 48Ahhh. You feel like you’re in a better place now. The sun is shining, you’re surrounded by friends, life is good. And is that a human-sized rabbit waving at you over there? Yes, you’re hallucinating. Even with their superb levels of fitness and body control, endurance athletes frequently see things that aren’t there. Take the experience of ultrarunner Steve Pero on the route of Colorado’s Hardrock 100 endurance run in 2013:
You’re losing your grip on reality – and heading towards a condition resembling acute psychosis. Along with this loss of conscious control is something even more alarming. Until now, throughout your whole life, your body has been working on your behalf, every second of every day, in such a staggeringly complex way that if you had to think about it, your conscious mind wouldn’t know where to start. Thankfully it’s all done automatically – because that’s the deal we make with our bodies. We give them the fuel and conditions they require to keep working, and they do that hard work for us. But now you’ve successfully withheld one of your body’s most basic needs, and it’s collapsing into anarchy. You’re now at increased risk of death from a multitude of conditions because your brain’s control of those autonomous processes is going awry – and that message hasn’t reached your conscious brain yet. You’re becoming increasingly hypometabolic, a common feature of neurodegenerative diseases, where your body is increasingly unable to manage your energy intake – and dysautonomia is kicking in, sending certain automatic nervous system processes into energy-burning overdrive. It’s a disastrous combo. Beyond this point, life gets very difficult indeed. Spare a thought for the sufferers of Fatal Familial Insomnia (FFI), a terribly cruel hereditary prion disease that attacks the part of the brain containing the thalamus and hypothalamus, which regulate the body’s metabolic processes, including its sleep cycles. The average survival time for FFI is 18 months – and there is no known cure. And as for you? Incapable of making the right call and hallucinating wildly, you’re stumbling forward into the death zone of sleeplessness. Now it’s a gruesome race between your dimming consciousness making a fatal judgement call and your body seizing up completely – and the finish-line can’t be far away. Lights out, friend.
How To Sleep BetterA recent survey suggested the 2020 COVID-19 lockdown had more than half of the population of the UK struggling to sleep. If you’re feeling reassured that you’ll never be daft enough to stay up for two or more days straight, you should bear in mind that accumulated sleep debt is almost as catastrophic for your health in the long-term – so you should act accordingly. However, making yourself sleep is impossible, as anyone can attest after a long night of turning hither and thither. All we can do is create the bodily and environmental conditions for sleep to arise naturally and overtake our forever racing minds. Which is, of course, damn hard work. You can find a wealth of advice on sleeping from medical experts online - being a Brit, I’d certainly start with the NHS’s page on it. But here are two powerful assists that I can recommend from personal experience. 1. Microdose On MelatoninMy friend Jodi Ettenberg who writes the newsletter Curious About Everythinghas a superbly well-researched article on managing the sleep disorder known as jet lag using microdoses of melatonin supplements. Fantastic piece, with links aplently, so I’d suggest you start your further reading there. (She also did a piece on Seasonal Affective Disorder that I recommend to you.) My own experience: due to a stressful few years with family stuff, I was suffering with enough insomnia to accumulate a crippling sleep debt, so I tried melatonin, bought over the counter in Spain. Within a week I’d upped my nightly sleep hours from five to seven, with a deeper, better-feeling quality of downtime every night - and not only did my energy levels start to creep up again, I also felt a lot more cheerful about life. 2. Sleep OutdoorsIn 2017, severely sleep-disturbed Outside editor Erin Berger set herself a challenge:
A week later:
The longest I’ve slept outside is 5 days in a row – but even 1 or 2 days is long enough to feel the benefits (as long as you’re comfortable, so if you’re camping or bivvy bagging, always bring an inflatable mat!). If you can manage once or even twice a week, maybe Friday and Saturday nights, that’d probably work nicely. If you let natural light guide you and stay away from your glowing gadgets after dark – and if you’ve grown accustomed to the modern-day weirdness of not being indoors – then you should be in for a terrific night’s sleep. Best of luck! References:
Images: Doğukan Şahin, Wilhelm Gunkel and Jimmy Conover on Unsplash.
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